NEW YORK, December 8, 2025 – U.S. markets closed on Monday with extreme polarization, as two biotech-related stocks headlined the biggest gainers and losers, while market activity was dominated by a high-volume frenzy in a penny stock and the consistent flow in chip giant NVIDIA. All figures are as of 4:16 PM ET.
The NASDAQ saw Top Wealth Group Holdings Limited (TWG) lead all advances, rocketing +271.16%, while biotech firm Wave Life Sciences Ltd. (WVE) was the third-highest gainer, jumping +147.26%. Meanwhile, its biotech peer, Security Matters Public Limited Company (SMX), saw a sharp decline, plummeting -59.09%.
🔥 Biotech Breakthrough and Caviar King Lead the Surge
Wave Life Sciences Ltd. (WVE) was a major story, surging +147.26% to close at $18.52. The dramatic move was fueled by positive interim Phase 1 data from its INLIGHT trial for its experimental obesity treatment, WVE-007.
The company reported that a single dose of the RNA therapy achieved significant body composition improvements, including a 9.4% reduction in visceral fat and a 4.5% drop in total body fat at three months.
Critically, the drug appeared to preserve lean muscle mass—a key advantage when compared to some other weight-loss medications on the market.
The stock was also highly active by share volume, recording 144,915,176 shares traded.
Following the market enthusiasm, Wave Life Sciences announced a proposed $250 million underwritten public offering of shares and pre-funded warrants.
Top Wealth Group Holdings (TWG), a supplier of sturgeon caviar, closed up an astonishing +271.16%. The massive jump followed an upbeat profit outlook announcement for the financial year 2025. The company projected a net profit of at least $4 million for FY2025, which would reverse a $2 million loss from the prior year.
📉 Plunge in High-Risk Stocks
The day's most significant declines were led by Security Matters Public Limited Company (SMX), which plummeted -59.09%. The security solutions firm's dramatic fall followed a volatile rally in recent trading days. Another associated security, SMXWW, also dropped sharply by -47.85%.
Other major decliners included:
SRV (NXG Cushing Midstream): Down -54.87%.
MHUA (Meihua Intl Medical Tech): Fell -45.72%.
NOTE (FiscalNote Holdings, Inc.): Dropped -44.51%.
💵 Trading Activity Snapshot
In terms of market activity, the volume leader was the low-priced stock Paranovus Entertainment (PAVS), which saw 1,295,287,027 shares change hands, closing slightly higher at $0.0489.
By dollar volume, which tracks the total value of shares traded, technology titans led the charge:
NVIDIA Corporation (NVDA) was the most active by dollar value, closing at $185.5745 and rising +1.73%. News surrounding its trading activity included the U.S. government allowing the shipment of certain high-powered chips to approved customers in China.
Tesla, Inc. (TSLA) saw heavy volume activity, closing lower at $439.58, down -3.38%.
Broadcom Inc. (AVGO) closed up +2.78% at $401.10 on high dollar volume.
