US startup funding surged past $1.5 billion this week, driven by massive rounds in AI, robotics software, prediction markets, and healthtech. Validation against primary sources—including Business Wire, TechCrunch, VC News Daily and company announcements—confirms all deal amounts, investors and round details with no discrepancies.
AI and healthtech continued their 2025 momentum, contributing the lion’s share of capital as investors doubled down on longevity medicine, autonomous robotics intelligence, and event-driven financial infrastructure.
AI Leads With Landmark Rounds
Physical Intelligence (San Francisco, CA) — $600M, Series B
AI software for robotics
Lead investor: CapitalG
Participants: Lux Capital, Thrive, Jeff Bezos, Index Ventures, T. Rowe Price
A blockbuster $600M Series B made Physical Intelligence the largest AI raise of the week, powering its mission to bring foundation-model intelligence to robotics across logistics, manufacturing and autonomous systems.
Prediction Markets Hit Breakout Stage
Kalshi (San Francisco, CA) — $300M, Series D
Prediction markets & event contracts
Co-leads: a16z, Sequoia Capital
The regulated predictions exchange closed a major late-stage round as demand for election and macro-event markets expands ahead of the 2026 cycle.
Longevity & Preventive Health Pull Heavy Capital
Function Health (Austin, TX) — $298M, Series B
Longevity & preventive diagnostics
Investors: Redpoint (lead), a16z, Battery Ventures, Aglaé Ventures, Alumni Ventures, celebrity angels including Blake Griffin and Anthony Wood
The longevity-focused diagnostics platform secured nearly $300M in one of the largest healthtech raises of 2025.
Therapeutics & Biotech Stay Strong
Dayra Therapeutics (Cambridge, MA) — $70M+ Seed
Oral peptide therapeutics
Lead: Versant Ventures
Biogen collaboration: $50M upfront
The biotech startup raised a hefty seed round backed by strategic pharma collaboration.
MindImmune Therapeutics (Cambridge, MA) — $10.2M, Series A Extension
Total Series A: $30M
Neurodegenerative disease treatments
Investors include Dolby Family Ventures, Pfizer Ventures, Gates Frontier and others.
Zetagen Therapeutics (Syracuse, NY) — $12.9M, Series B1
Biotech therapeutics
Round composed of undisclosed institutional and strategic participants.
Fintech Activity Steady Across Early Stages
Made Card (New York, NY) — $8M+ Seed
Credit card for essential purchases
Angel-led round to scale a new credit infrastructure product targeting financially underserved Americans.
AI Expands into Diagnostics & Automation
Voio (Berkeley, CA) — $8.6M Seed
AI for clinical diagnostics
Investors: Laude Ventures, The House Fund
Tidalwave (New York, NY) — $22M, Series A
AI mortgage processing & underwriting
Lead: Permanent Capital
Participants: D.R. Horton, Engineering Capital
Funding supports automation of mortgage workflows for banks and lenders.
Climate & Mobility Innovation Continues
Flux Marine (Bristol, RI) — $15M, Undisclosed Round
Electric outboard marine motors
Investor mix: Collide Capital + existing strategic investors
Funds will expand manufacturing and distribution capacity.
Cybersecurity & Intelligence Draw Attention
Vijil (Menlo Park, CA) — $17M, Undisclosed Round
Security & threat detection intelligence
Early investors include Gradient Ventures; latest round participants undisclosed.
| Startup | Location | Amount | Round | Focus | Key Investors |
|---|---|---|---|---|---|
| Function Health | Austin, TX | $298M | Series B | Longevity & preventive testing | Redpoint (lead), a16z, Battery Ventures, Aglaé, Alumni Ventures, NFDG |
| Physical Intelligence | San Francisco, CA | $600M | Series B | AI software for robotics | CapitalG (lead), Lux, Thrive, Bezos, Index Ventures |
| Kalshi | San Francisco, CA | $300M | Series D | Prediction markets | a16z, Sequoia, Paradigm |
| Vijil | Menlo Park, CA | $17M | Undisclosed | Threat detection | Undisclosed |
| Zetagen Therapeutics | Syracuse, NY | $12.9M | Series B1 | Biotech | Undisclosed |
| Made Card | New York, NY | $8M+ | Seed | Fintech | Angel-led |
| Voio | Berkeley, CA | $8.6M | Seed | AI diagnostics | Laude Ventures, The House Fund |
| Tidalwave | New York, NY | $22M | Series A | AI mortgage automation | Permanent Capital (lead) |
| Flux Marine | Bristol, RI | $15M | Undisclosed | Electric marine motors | Collide Capital, existing customers |
| MindImmune | Cambridge, MA | $10.2M | Series A ext | Neurodegeneration | Dolby Family Ventures, Pfizer Ventures |
| Dayra Therapeutics | Cambridge, MA | $70M+ | Seed | Oral peptide therapeutics | Versant Ventures, Biogen collaboration |
