New York | Jan 22, 2026: U.S. equities witnessed sharp stock-specific moves on Thursday, with select micro- and mid-cap names posting extreme gains and losses, while heavyweight ETFs and large-cap tech stocks dominated trading volumes.
Top Gainers: Explosive Upside in Select Stocks
Spring Valley Acquisition Corp. (SVACW) emerged as the biggest gainer of the session, soaring 301.9%, leading the list of most-advanced stocks.
Other notable gainers included:
60 Degrees Pharmaceuticals (SXTP): up 152%
IO Biotech, Inc. (IOBT): gained 131.3%
Arbe Robotics (ARBEW): rose 109.4%
Dermata Therapeutics (DRMAW): advanced 105.8%
The rally in these names was accompanied by unusually high trading volumes, indicating strong speculative interest.
Top Losers: Sharp Sell-Offs in Select Counters
On the downside, PLAYSTUDIOS, Inc. (MYPSW) led losses, plunging 50.4%, making it the worst performer of the day.
Other significant decliners included:
Reliance Global Group (RELIW): down 38.5%
ITHAX Acquisition Corp. (ITHAW): fell 36.6%
C3is Inc. (CISS): declined 35.5%
Carbon Revolution Plc (CREVW): slipped 29%
Most Active Stocks: Volume-Driven Trading
By share volume, IO Biotech (IOBT) topped the charts with over 467 million shares traded, closing at $0.4801, followed by:
Healthcare Triangle (HCTI)
Direxion Daily Semiconductor Bear ETF (SOXS)
60 Degrees Pharmaceuticals (SXTP)
Plug Power (PLUG)
By dollar volume, large-cap and ETF heavyweights dominated:
SPDR S&P 500 ETF (SPY) closed at $688.73, up 0.49%
Tesla (TSLA) surged 4.15% to $449.36
NVIDIA (NVDA) gained 0.77%
Invesco QQQ Trust (QQQ) rose 0.73%
Micron Technology (MU) climbed 2.18%
Market Takeaway
Thursday’s session highlighted a clear divergence in market behaviour—high volatility and speculative momentum in smaller stocks, alongside steady institutional participation in large-cap technology and index ETFs. Traders are expected to remain stock-specific amid earnings season and macro-economic cues.
